AUC = area under the curve (parasites/ mL) P total = total parasitemia (parasites/ mL) P max = maximum peak of parasites (parasites/ mL) Day of P max = Day of maximum peak of parasites P 8thDI = number of tripomastigotes on 8 th day of infection (parasites/ mL) 2 nd P max = number of tripomastigotes in the 2 nd peak of parasites (parasites/ mL) Day of 2 nd P max = Day of 2 nd peak of parasites 2 ndPEAK n/N = number of animals that showed 2 nd peak of parasites (n)/ total number of infected animals (N) x 100. Statistical significance (p < 0.05* and p < 0.01**) compared to control group: CI: control group – infected animals treated with 7% ethanol-water solution diluted in water (10μL/mL) offered ad libitum BIOT PI: infected animals treated with biotherapic BIOT Tc17dH diluted in water (10μL/mL) offered ad libitum from the day of the infection until the death of the animals BIOT 4PI: infected animals treated with biotherapic BIOT Tc 17dH diluted in water (10μL/mL) offered ad libitum from the 4 th day of the infection until the death of the animals BIOT 4-5–6: infected animals treated with biotherapic BIOT TC 17dH by gavage on the 4 th, 5 th and 6 th day of the infection BIOT 7-8–9: infected animals treated with biotherapic BIOT TC 17dH by gavage on the 7 th, 8 th and 9 th day of the infection. The present study evaluated in vivo the effect of different treatment schemes using the biotherapic Trypanosoma cruzi 17dH (BIOT Tc17dH) in an experimental infection by this protozoan. cruzi is a possible means to understand the effect of these highly diluted medications and to find new candidates to treat Chagas disease. Therefore, using biotherapics as an intervention in murine infection with T. Īccording to the literature, morbidity is related to the presence of the parasite, and pathogenesis increase is the result of a disruption of the host-parasite relationship. Therefore, the murine model is an excellent experimental model for the evaluation of drug interventions.
Extensively studied in experimental murine models, it shows well-defined characteristics such as high parasitemia, peak of parasites by the 12 th day of infection, death of all untreated infected animals, and partial resistance to drugs classically used in the treatment of human Chagas disease. cruzi Y is considered a reference strain. However, no effective drug for etiological treatment has been discovered so far. Ĭhagas disease, caused by the protozoan Trypanosoma cruzi, has been studied for more than a century. Although experience in clinical practice using biotherapics cannot be ignored, academic research on biotherapics has been questioned. īiotherapics are highly diluted medications prepared according to homeopathic techniques from biological products, including the etiological agent itself.
Īlthough several studies have attempted to explain the clinical results of highly diluted medications, few trials have evaluated the effect of different treatment schemes with these drugs on living organisms. cruzi, one study reported an increase in the apoptosis rate and a decrease in the secretion of TGF-β measured in serum collected from the group treated with biotherapic medication, compared with the control group. (2007) suggested that homeopathic medicine can regulate inflammatory and immunopathological processes as well as the neuroendocrine network and peripheral receptors.
One of the hypotheses regarding the therapeutic effect of these drugs is that they modulate the immune system, and understanding the dynamics of this effect depends on the recognition of the information systems involved. The use of highly diluted medications in the treatment of parasitic diseases has been investigated, but the available information does not allow us to demonstrate details of their effects.
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